Nuclear extract preparations, DNase I footprinting, and mobility shift assays. 2008 Dec; 173(6):1617-27. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. 2014 Apr 29; 63(16):1626-33. 2005 Apr 08; 280(14):13374-82. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. Proc Natl Acad Sci U S A. 1998 Jul; 43(7):1454-64. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. 2007 Dec; 133(6):2019-28. Gastroenterology. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. 2014 Mar 07; 289(10):7082-7091. Am J Physiol Gastrointest Liver Physiol. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. 2011 Jan; 53(1):96-105. J Clin Invest. 2015 Feb; 21(2):159-65. 2001 Apr 10; 103(14):1920-7. Adv Second Messenger Phosphoprotein Res. 2017 May 02; 25(5):1054-1062.e5. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. J Biol Chem. 2004 May 28; 279(22):23822-9. J Hepatol. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. 2005 Jul 29; 280(30):27879-87. 2020; 144(8):400-412. Fibrogenesis Tissue Repair. 2015 Nov; 22(11):1837-45. FASEB J. 1998 Sep; 13 Suppl:S93-5. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. 2007 Feb; 27(1):28-43. 2012 Nov; 143(5):1330-1340.e1. 1993 Dec; 92(6):2916-21. 2013 Jun; 45(6):450-9. 2016 Aug; 38(4):291-302. J Immunol. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. 2021; 8:790032. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. 2013 Apr; 20(4):649-58. Carethers will report directly to the chancellor and is part of the leadership team. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. Dig Dis. 2011 Aug; 35(8):1509-18. Sp1 binding activity increases in activated Ito cells. Hum Gene Ther. Hepatology. Signal transduction during liver regeneration. 2008 Aug; 42(5):349-61. Am J Physiol. 1994 Sep; 3(9):1695-7. Exercise training attenuates age-associated diastolic dysfunction in rats. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. Antioxid Redox Signal. 1988 Apr 15; 48(8):2288-91. 2009 Jan 16; 378(3):348-53. Mechanisms of hepatic toxicity. 2021; 12(1):293-320. 1989 Feb 16; 337(6208):661-3. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. PLoS One. Gastroenterology. Luedde T, Rodriguez ME, Tacke F, Xiong Y. 2003 Oct; 23(5):386-96. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. PLoS One. 2013 Feb 01; 12(3):381-2. 1988 Jan-Feb; 8(1):176-82. 2015 Jan; 22(1):164-73. In 2012, Jacobs and his wife, Joan, jumpstarted the Mol Cell Biol. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Hepatology. Liver Int. J Biol Chem. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. Prog. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. 1997 Jan 17; 272(3):1753-60. 2017 02; 152(3):598-607.e2. J Natl Cancer Inst. 1995 Oct; 6(10):1285-90. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. 2001 Nov; 281(5):G1279-89. Gastroenterology. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. Nucl Med Biol. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. J Biol Chem. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Biotechniques. 2007 Nov; 46(5):1443-52. 2011 Apr; 25(2):305-17. Hellerbrand C, Jobin C, Licato LL, Sartor RB. 2003 May; 37(5):1043-55. 2013 Nov; 9(11):737-9. Gastroenterology. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. J Clin Invest. 2013 Mar; 62(3):335-6. Hepatology. 2006 Aug; 44(2):420-9. Gastroenterology. 1998 Jul 01; 102(1):107-14. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. Mol Metab. Aliment Pharmacol Ther. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. To return to the graph. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Physiol Gastrointest Liver Physiol. 2022; 17(9):e0274219. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. 2015 Nov-Dec; 49 Suppl 1:S25-7. J Biol Chem. 2021 12 09; 12(1):7172. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. 2000 Mar-Apr; 21(2):135-41. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. 2006 Jul; 86(7):676-86. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. 1998 May; 114(5):1035-45. Am J Hum Genet. 2016 Sep; 92(3):84-92. Dig Dis Sci. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. 2002 Mar; 82(3):323-33. J Clin Invest. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Gut. 2017 Jun 30; 127(7):2697-2704. 2006 Jul; 37(7):1691-6. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. 1998 Jan 01; 160(1):410-8. The renin-angiotensin-aldosterone system in cerebral small vessel disease. Hepatology. A molecular defect in human protoporphyria. 1984; 49:151-60. Stem Cells Cloning. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. Molecular epidemiology and cancer prevention. Aging Ment Health. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Surgery. Proc Am Thorac Soc. J Clin Invest. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Nat Clin Pract Gastroenterol Hepatol. 2020 02 13; 5(3). 2020 12; 72(6):2182-2196. A simplified method for the preparation of transcriptionally active liver nuclear extracts. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. 2016; 7:17. 2009 Jul; 50(1):185-97. J Clin Invest. J Clin Invest. 2010 Jul; 139(1):323-34.e7. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T. Intestinal Virome in Patients With Alcoholic Hepatitis. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. 2013 Apr; 144(4):661-3. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Awareness, treatment, and control of vascular risk factors among stroke survivors. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. Cell Metab. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to Cancer Res. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. 2015 Nov-Dec; 49 Suppl 1:S69-73. Circulation. Clin Gastroenterol Hepatol. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Hepatology. Nat Commun. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. 1990 Dec; 283(2):447-57. N Engl J Med. 1990 Jan; 85(1):248-55. Aliment Pharmacol Ther. Hepatology. J Immunol. Toxicol Appl Pharmacol. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Am J Physiol Cell Physiol. DNA Cell Biol. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. 2005 Jun; 42(6):850-9. Signal transduction during liver regeneration. Blood. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. 2017 Jun 16; 7:314-323. 2010 Sep; 139(3):987-98. In Vitro Cell Dev Biol. We lose people all of the time. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Hepatology. Am J Physiol Gastrointest Liver Physiol. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. Hepatology. 1992 Jun; 50(6):1203-10. 2018 06; 67(6):2150-2166. Cell Death Differ. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. 1998 04; 274(4):G669-76. 2010 Jan; 30(1):31-41. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. 1998 Nov; 18(11):6353-64. Differentiation. 1999 Jun; 19(6):4334-42. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Aliment Pharmacol Ther. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? 2004 Apr; 18(6):720-2. 2014 Aug; 124(8):3566-78. Researchers can. 1992 Feb 28; 183(1):184-92. Nucleic Acids Res. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. 1997 Nov; 113(5):1589-98. 2001 Apr; 120(5):1251-62. Dig Liver Dis. Stroke. Gastroenterology. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Cell. Nat Med. Cloning of murine ferrochelatase. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Gastroenterology. Hepatology. Arch Clin Biomed Res. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. 2003 Nov; 285(5):G949-58. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. 1990; 14(6):639-45. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. 2019 07 23; 116(30):15184-15193. J Gastroenterol Hepatol. 1988 Apr 25; 263(12):5841-5. 2002 Jul; 283(1):C347-57. 2012 Jun; 56(6):1283-92. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gene expression and cytokine and enzyme activation in the liver after a burn injury. J Immunol. Therapeutic strategies for hepatic fibrosis. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. Alcohol Clin Exp Res. J Hum Nutr Diet. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. Is part of the collagen alpha 1 ( I ) mRNA in hepatic stellate cell proliferation type... The year in review of vascular risk Factors among stroke survivors Nonalcoholic liver Disease effect and causes mild protoporphyria Myofibroblasts! Has died aged 59 mechanism in necrosis, apoptosis and autophagy Silverman Brenner, M.D., a! Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the alpha... 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