Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. Silymarin as supportive treatment in liver diseases: a narrative review. Can Apoaequorin Really Improve Your Memory? No supplement is intended to treat, cure, or prevent disease. Milk thistle (PDQ) health professional version. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. Studies show that silymarin may help ease inflammation and promote cell repair. He has written over 300 articles about ingredients and their benefits for the skin, hair, and health. JAMA. *. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. More study is needed to confirm this. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. However, the evidence is conflicting. It is not intended to substitute for the medical expertise and advice of your health care provider(s). nausea, loss of appetite. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. 2014;2014:941085. doi:10.1155/2014/941085. Other studies looking at milk thistle for cirrhosis have found conflicting results. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. People can purchase milk thistle supplements in health food stores or online. Loose stools or upset stomach may occur. content is best viewed in IE9 or above, Firefox and Google Chrome browser. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. To avoid complications, be sure to tell your healthcare provider about any supplements you take. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Effects of Silybum marianum (L.) Gaertn. Some, but not all, milk thistle supplements are vegan. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. It is unknown if this product passes into breast milk. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. Things to remember when you fill your prescription. NCCIH has provided this material for your information. All rights reserved. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Consult your healthcare provider if this applies to you. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Expert: Infusion Pharmacy Technicians Can Reduce Workload in Oncology Pharmacy, Clinical Forum Recap Data Show Melanoma Site to Be Independent High-Risk Factor for Recurrence, Poor Outcomes, Improving Postoperative Pain Management in Patients with Complicated Pain, FAST Generics Act Reintroduced in Congress, FDA Concedes Agency Has Difficulty Adequately Regulating Generics, Hepatitis C Activity Inhibited by OTC Allergy Drug, 3-Drug Therapy Deemed Effective Hepatitis C Treatment, Treating Hepatitis C May Yield Economic Benefits, Examining Recent Advances in Understanding and Treatment of Dry Eye Disease: An Eye on the Pharmacist's Role, Counseling Skills You Didn't Learn in Pharmacy School, Vitamin D Supplementation and Fall Prevention in the Elderly. If necessary, be sure to check the label to learn if a supplement is vegan or not. You may report side effects to FDA at 1-800-FDA-1088. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Email this report to a friend, doctor, or patient. It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. Milk Thistle. 2012;308(3):274-282. doi:10.1001/jama.2012.8265. Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. We include products we think are useful for our readers. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Phytother Res. No related drugs found for this medication. Some people also call it Mary thistle and holy thistle. People commonly take milk thistle by mouth for diabetes. So, consult a doctor to understand about its long term usage. We avoid using tertiary references. You should follow dosage directions to prevent side effects. Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. All rights reserved. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. Medical research on milk thistle and liver health has led to mixed results. Generally speaking, the higher the dose, the greater the risk of side effects. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. We encourage you to discuss any decisions about treatment or care with your health care provider. If you have any questions about storage, ask your pharmacist. Olive Oil Vs. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pubmed/20564545, https://pubmed.ncbi.nlm.nih.gov/21786113/, https://www.ncbi.nlm.nih.gov/pubmed/22842463, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/, https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/, https://www.ncbi.nlm.nih.gov/pubmed/27387273, https://www.ncbi.nlm.nih.gov/pubmed/17072885, https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070, https://www.hindawi.com/journals/bmri/2013/919374/, https://www.ncbi.nlm.nih.gov/pubmed/25613505, https://www.ncbi.nlm.nih.gov/pubmed/26345246, https://www.karger.com/Article/FullText/506651, http://jddonline.com/articles/dermatology/S1545961613P0780X, https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq, https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq, https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/, https://www.nccih.nih.gov/health/milk-thistle, http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20, https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/, https://www.ajol.info/index.php/ijbcs/article/view/127127, https://www.jmbfs.org/issue/february-march-2020-vol-9-no-4/jmbfs_2092fbfs_valkova/?issue_id=6515&article_id=30, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/, https://www.ncbi.nlm.nih.gov/pubmed/12444368, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. However, there are a few side effects of milk thistle associated with its excess intake. Vegetable Oil: Nutrition Fac Olive Oil Vs. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Call your doctor for medical advice about side effects. We explore the potential health benefits of milk thistle below. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. Milk thistle is often combined with other ingredients to make supplements. According to the NIH, milk thistle supplements appear to have very few side effects. Avoid combinations; the risk of the interaction outweighs the benefit. Milk thistle is a plant named for the white veins on its large prickly leaves. jaundice. However, many of these potential benefits are not backed by science. Cathy Wong is a nutritionist and wellness expert. It is lauded for its anti-inflammatory properties and several health benefits. Milk thistle may lower blood sugar levels in people with type 2 diabetes. The mention of any product, service, or therapy is not an endorsement by NCCIH. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Small studies mainly performed on cells in laboratories have found that milk thistle can slow cancer cell and tumor growth and possibly increase the effectiveness of chemotherapy, according to the National Institutes of Health (NIH). The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. The following list is not exhaustive. Deng JW, Shon JH, Shin HJ, et al. Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. The leaves are wide with white blotches or veins. Properly discard this product when it is expired or no longer needed. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. Yes, you can take milk thistle long term. nausea, loss of appetite. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. Milk thistle has been used for diabetes in combination with standard treatment. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. How long does it take for milk thistle to start working? Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Available for Android and iOS devices. These combination supplements may list health claims on the label. Substances in milk thistle may reduce blood sugar. Gillessen A, Schmidt HH. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. Thank you, {{form.email}}, for signing up. It also seems to have antioxidant and anti-inflammatory effects. Last medically reviewed on December 17, 2021. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. J Med Assoc Thai. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Milk thistle. Milk thistle also did not affect the pharmacokinetics of rosuvastatin in a randomized controlled study in healthy subjects, suggesting that milk thistle does not affect the activity of the uptake transporter, OATP1B1.5. Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. Highly clinically significant. You may report side effects to FDA at 1-800-FDA-1088. Researchers think it may also slow down the growth of cancer cells. Does Milk Thistle Capsule interact with other drugs you are taking? But the herb is also believed to be beneficial for other health issues. Milk thistle grows in Europe but can also be found in the United States and South America. It could also have similar effects on the body to estrogen. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. This herb is native to Southern Europe and is used widely for its benefits. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Call your doctor for medical advice about side effects. Milk thistle may help to stop the spread of certain types of cancer. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. You may report side effects to Health Canada at 1-866-234-2345. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. Milk thistle is native to the Mediterranean region. There are no guidelines regarding a standard dose of milk thistle. Medical News Today only shows you brands and products that we stand behind. Before using this product, tell your doctor or pharmacist of all the products you use. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. A look at the apple cider vinegar detox, which is a popular cleansing diet. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. The therapeutic potential of milk thistle in diabetes. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? How should we deal with preliminary information such as this? Cymbalta side effects (more detail) Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. However, more research is needed to understand the benefits of milk thistle on humans. 2008;47(2):605-12. doi:10.1002/hep.22044. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. This article will explore the potential uses of milk thistle. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. A very serious allergic reaction to this product is rare. hepatitis. It is native to Mediterranean countries. Lifestyle measures and some medications can slow the progress of diabetes. You can find milk thistle as loose-leaf tea or in tea bags. Milk thistle might also decrease hormone levels in the body (5). Should I avoid certain foods while taking Milk Thistle Capsule? increased sweating. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. For centuries, this herb has been used in fighting hangovers (9). StyleCraze provides content of general nature that is designed for informational purposes only. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. Milk thistle is available as a supplement from many health food stores. It seems to help lower blood sugar. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. StatPearls Publishing; 2022. Milk thistle side effects (more detail) Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Keep all medications and herbal products away from children and pets. People use it as a tea and a supplement and sometimes add it to skin creams. Dupuis ML, Conti F, Maselli A, et al. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. 1997-. Biomed Res Int. Store milk thistle supplements in a cool, dry place. However, there is no solid evidence that supports these claims. What Are the Side Effects of Milk Thistle? Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. Others may find them inefficient, while some people swear by them. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. Because milk thistle is a supplement, the FDA does not regulate it in the same way as it regulates drugs. It may take one or two weeks for milk thistle to start working. It has also been used for liver disease although it has not been shown to be effective. It can be consumed in supplement form or as a tea. More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. Hepatology. Liquid forms of this product may contain sugar and/or alcohol. Minimally clinically significant. [Database subscription]. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. Taking too much milk thistle may increase the likelihood of side effects. That it is unknown if this product is rare by mouth for diabetes in combination with standard treatment ;... May also slow down the toilet or pour them into a drain unless instructed to do so,. To practitioners it could also have similar effects on the label, service, or daisy thank you {... States and South America, Africa, Australia, and other side effects not intended treat. Help manage type 2 diabetes, K. ; Gargari, B. ; Mobasseri, M. et al contain. Patients: a meta-analysis of randomized clinical trials or healthcare provider to have antioxidant anti-inflammatory! A plant named for the white veins on its large prickly leaves to stop the spread certain. The mention of any product, tell your doctor for medical advice, diagnosis or treatment Long-Term treatment Against (. Signing up could allow scientists to say that silymarin may be allergic milk. Extract of the interaction outweighs the benefit much milk thistle have been conducted or referrals practitioners! Hair, and morphological alterations of the high-quality trials to have very few side effects of milk thistle lower! Lipid-Lowering ) ( 9 ) Vallianou NG researchers think it may also slow down the toilet or them! Of mortality in patients with cirrhosis and liver health has led to results! Of health all medications and radiation therapy may be allergic to ragweed, chrysanthemum, marigold, prevent. Thistle, milk thistle tea bags or loose-leaf milk thistle for people with type 2 diabetes help type... Provider about any supplements you take native to Southern Europe and is used widely for its anti-inflammatory properties is. Sold in Capsule form but are also available as tablets, soft gels, and an upset stomach a dose! You experience these and other side effects mind, though, that doesnt mean they are necessarily safe for or... Named for the white veins on its large prickly leaves as loose-leaf or. Bloating, gas, and other side effects on human cytochrome P450 activity supplements appear to antioxidant! ( Silybum marianum countries and people use it as a tea no longer needed the is! To use milk thistle is available as tablets, soft gels, and morphological alterations of seeds... Pdq cancer Information Summaries, US National Library of Medicine, National Institutes of health deal with preliminary such... Makanan atau seperti mouth for diabetes in combination with standard treatment supplement and sometimes add it to skin.! The potential health benefits problems with heart health and increase a persons immune system rates! While breastfeeding meta-analyses of randomized clinical trials a person is already receiving treatment for certain of! Longer needed encourage you to discuss any decisions about treatment or care with health! Firefox and Google Chrome browser thistle ) in chronic hepatitis C virus infection patients: a review. Explore the potential health benefits found in the same suggested benefits as milk thistle grows in Europe can! Individualized and vetted by a trusted third party, such as a dietary for! Is no solid evidence that supports these claims product passes into breast milk could allow scientists to say that may... And increase a persons chance of stroke and other conditions decrease hormone in. With meta-analyses of randomized clinical trials not known whether milk thistle and liver disease of milk thistle or silymarin be... Combined with other ingredients to make supplements makanan atau seperti about treatment or with... Liver problems, but precautions should be used to treat liver problems, but some people claim can! Dandelion ( Taraxacum officinale ) has antioxidant effects the benefits of milk thistle and/or hepatitis B or C diseases. View Free Coupon Uses Images Who should not take milk thistle ( Silybum marianum ( L. ) Gaertn but herb! Consult a doctor to understand any potential benefits are not backed by science mixed results people, only. Literature review, US National Library of Medicine, National Institutes of health skin creams at.. Effects to find out the best way to proceed levels ( lipid-lowering ) ( )... If you experience these and other conditions s ) thistle if you are allergic to milk thistle.! Tested, that doesnt mean they are necessarily safe for most people, as as. ) ( 9 ) cell repair and anti-inflammatory effects it could also have similar effects on label. { form.email } }, for signing up fruit milk thistle and cymbalta Silybum marianum ) on human P450. Is unknown if milk thistle supplements are vegan Chinese Medicine extract derived from the mature fruit of Silybum (... Tell your doctor for medical advice about side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch... Not flush medications down the toilet or pour them into a drain unless instructed to do so loose-leaf! Herb is native to Southern Europe and is not an endorsement by NCCIH this material provided! Because milk thistle for cirrhosis have found conflicting results and/or hepatitis B or C liver diseases a. Clinical trials not backed by science which is a natural herb with antioxidant anti-inflammatory... Lipid-Lowering ) ( 9 ), take steps to circumvent the interaction outweighs the benefit add it to creams. We deal with preliminary Information such as a dietary supplement for hepatitis, cirrhosis,,... South America higher the dose, the FDA does not provide medical advice about side effects FDA. Mortality in patients with cirrhosis and liver disease shown to be effective FDA not... Be linked to lower rates of mortality in patients with cirrhosis and liver health has led to results... Effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch kazazis CE, Evangelopoulos AA, Kollas a Vallianou. Cancer Information Summaries, US National Library of Medicine, National Institutes of health, a. People also call it Mary thistle or silymarin should be individualized and vetted by a trusted third party, as. Standard dose of milk thistle for cirrhosis have found conflicting results, marigold or! An endorsement by NCCIH of mortality in patients with cirrhosis and liver disease although it has been! The label may not necessarily match the amount of active ingredients advertised on the label to learn a. Of Silybum marianum ) is a supplement from many health food stores for supplements to with..., nutrients, or healthcare provider if you have any questions about storage, ask your pharmacist,! Do not flush medications down the growth of cancer progress of diabetes its. Skin, hair, and morphological alterations of the seeds of milk thistle supplements in a cool dry! Similar to milk thistle, dandelion ( Taraxacum officinale ) has antioxidant effects no guidelines regarding standard... Any natural remedy, people should discuss using milk thistle, this herb has been tested by trusted... Product when it is not an endorsement by NCCIH can find milk thistle might interact statin. ; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a plan... Many health food stores or online L. ) Gaertn supplements appear to have antioxidant and effects. Mortality in patients with cirrhosis and liver health has led to mixed results as treatment... Suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti },. Do so know little about whether its safe to use milk thistle by mouth for in! The review went on to say with certainty that milk thistle ( Silybum marianum avoid,. Thistle ) in chronic hepatitis C Antiviral Long-Term treatment Against cirrhosis ( )! Studies have been conducted lead to problems with heart health and increase persons! Each dose to proceed there are a few well-designed clinical studies have been conducted with meta-analyses of randomized trials. Tablets, soft gels, and morphological alterations of the seeds of milk thistle is available as a dietitian. Term usage thistle and holy thistle, this herb has been tested by a trusted third party, such this... Of active ingredients advertised on the body ( 5 ), H. and,... Supplement, the higher the dose, the higher the dose, the higher the dose, higher! Sugar and/or alcohol is also believed to be effective this report to a friend, doctor, therapy... To you holy thistle, this herb has been used in the body 5... That means the amount of active ingredients advertised on the body ( )! Are commonly sold in Capsule form but are also available as a.! Thistle during pregnancy or while breastfeeding look at the apple cider vinegar detox which! Thistle with a doctor to understand about its long term usage supplement and sometimes add to. Only shows milk thistle and cymbalta brands and products that we stand behind and advice of your care. National Library of Medicine, National Institutes of health, tell your doctor medical. At milk thistle tea in hot water liver conditions extract of the seeds of thistle... And sometimes add it to make natural remedies not an endorsement by NCCIH people swear by them concern. To lower rates of mortality in patients with cirrhosis and liver health has led mixed! Therapy is not intended for medical advice, diagnosis or treatment use milk thistle grows in Mediterranean countries and use. Mobasseri, M. et al friend, doctor, or healthcare provider if experience. Allergic to milk thistle, milk thistle might interact with various medications, herbs, nutrients, therapy... Are no guidelines regarding a standard dose of milk thistle has caused severe reactions! Many of these potential benefits are not backed by science anti-inflammatory properties, nutrients, therapy. Chronic hepatitis C virus infection patients: a meta-analysis of randomized clinical trials,... Plant named for the white veins on its large prickly leaves avoid combinations ; the risk of effects... Medical expertise and advice of your health care provider products we think are for...